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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE3A All Species: 7.88
Human Site: T488 Identified Species: 14.44
UniProt: Q14432 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14432 NP_000912.3 1141 124979 T488 N P V M M T L T K S R S F T S
Chimpanzee Pan troglodytes XP_520783 1141 125048 T488 N P V M M T L T K S R S F T S
Rhesus Macaque Macaca mulatta XP_001096963 1141 124707 V488 S L L S V L L V X X X X X X X
Dog Lupus familis XP_854529 779 87136 K207 D T A N F L A K P G V I L H R
Cat Felis silvestris
Mouse Mus musculus Q9Z0X4 1141 124494 T485 S W N A P G L T T L T K S R S
Rat Rattus norvegicus Q62865 1141 124282 M485 S W N A P V L M T L T K S R S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518516 340 38206
Chicken Gallus gallus XP_416416 825 91797 S253 K V L T A T Q S A P S L S E P
Frog Xenopus laevis NP_001088828 985 108702 G413 N S P S L G S G F S R A P V E
Zebra Danio Brachydanio rerio XP_695432 1117 123518 S422 N S D S W N N S N M L S I S K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W4T4 1209 129395 I423 S R I V L A P I G S A G G S S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q8I0P7 625 69850 M53 G V M S D G H M Q R T F H E A
Sea Urchin Strong. purpuratus XP_793920 1558 171759 A828 N S R S S S P A P L S R Q G G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.5 38.2 N.A. 84 84.6 N.A. 20.9 59.6 43.9 57.8 N.A. 20.8 N.A. 26.7 29.9
Protein Similarity: 100 99.7 98.4 49.6 N.A. 89.3 90 N.A. 25.1 63.9 58.3 71.2 N.A. 36.3 N.A. 37.9 43.2
P-Site Identity: 100 100 6.6 0 N.A. 20 13.3 N.A. 0 6.6 20 13.3 N.A. 13.3 N.A. 0 6.6
P-Site Similarity: 100 100 26.6 6.6 N.A. 26.6 20 N.A. 0 20 33.3 26.6 N.A. 46.6 N.A. 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 16 8 8 8 8 8 0 8 8 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 16 8 % E
% Phe: 0 0 0 0 8 0 0 0 8 0 0 8 16 0 0 % F
% Gly: 8 0 0 0 0 24 0 8 8 8 0 8 8 8 8 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 8 8 0 % H
% Ile: 0 0 8 0 0 0 0 8 0 0 0 8 8 0 0 % I
% Lys: 8 0 0 0 0 0 0 8 16 0 0 16 0 0 8 % K
% Leu: 0 8 16 0 16 16 39 0 0 24 8 8 8 0 0 % L
% Met: 0 0 8 16 16 0 0 16 0 8 0 0 0 0 0 % M
% Asn: 39 0 16 8 0 8 8 0 8 0 0 0 0 0 0 % N
% Pro: 0 16 8 0 16 0 16 0 16 8 0 0 8 0 8 % P
% Gln: 0 0 0 0 0 0 8 0 8 0 0 0 8 0 0 % Q
% Arg: 0 8 8 0 0 0 0 0 0 8 24 8 0 16 8 % R
% Ser: 31 24 0 39 8 8 8 16 0 31 16 24 24 16 39 % S
% Thr: 0 8 0 8 0 24 0 24 16 0 24 0 0 16 0 % T
% Val: 0 16 16 8 8 8 0 8 0 0 8 0 0 8 0 % V
% Trp: 0 16 0 0 8 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _